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Sense21 · Project

Regenerative Protein Therapies for Chronic Neuropathic Pain and Hearing Loss

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Imagine your nerves are like frayed electrical wires that cause 'static' in the form of pain or silence in the form of deafness. Instead of just masking the symptoms with painkillers, these proteins act like a repair kit to fix the wires and the insulation around them. This helps the body heal the actual damage rather than just numbing the feeling.

By the numbers
100M
Patients in the EU affected by pain and hearing loss
The business problem

What needed solving

Current treatments for chronic pain rely on CNS drugs that cause cognitive impairment and addiction, while hearing loss has no reparative medical options beyond amplification devices.

The solution

What was built

Two therapeutic proteins, HB-086 and HB-097, designed to regenerate sensory nerve fibers and normalize neuronal-glial crosstalk.

Audience

Who needs this

Pharmaceutical companies specializing in neurologyBiotech firms focused on regenerative medicineSpecialized pain management clinicsHearing restoration research centers
Business applications

Who can put this to work

Pharmaceuticals
enterprise
Target: Biotech drug developer

If you are a biotech drug developer dealing with the high failure rate of CNS-targeting painkillers — this project developed HB-086 and HB-097 that target sensory nerve cells directly to abolish pain without the dizziness or addiction associated with opioids.

Audiology
mid-size
Target: Medical device and therapy provider

If you are a medical therapy provider dealing with the limitation that hearing aids only amplify sound but cannot fix nerves — this project developed HB-097 that preserves the sense of hearing by protecting sensory nerve fibers.

Oncology Support
any
Target: Cancer care clinic

If you are a cancer care clinic dealing with patients who stop chemotherapy due to chronic nerve pain — this project developed a protein therapy that prevents and treats chemotherapy-induced pain to improve patient survival rates.

Frequently asked

Quick answers

What is the cost or pricing for these therapies?

Based on available project data, specific pricing and cost structures are not provided.

Can this be produced at an industrial scale?

Based on available project data, the project focuses on preclinical validation and therapeutic protein development; industrial scaling details are not mentioned.

Who holds the IP and licensing rights?

Hoba Therapeutics holds the rights to and is developing the two molecules, HB-086 and HB-097.

What is the expected dosing frequency?

The documented prolonged effects of the proteins warrant biweekly or monthly dosing.

How does this integrate with existing treatments?

It serves as a replacement or alternative to antiepileptics, antidepressants, and opioids by targeting the peripheral sensory system instead of the central nervous system.

Consortium

Who built it

The project is led by a single SME, Hoba Therapeutics ApS from Denmark. With a 100% industry ratio and no university or research institute partners, the project is streamlined for commercial development and direct control of the intellectual property.

How to reach the team

Contact Hoba Therapeutics ApS in Denmark

Next steps

Talk to the team behind this work.

Contact us to explore licensing opportunities for HB-086 and HB-097.

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