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RESPONSE · Project

Real-time Imaging to Detect Cancer Treatment Failure in Days Instead of Months

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Imagine if doctors could tell if a cancer drug is working within days instead of waiting months to see if a tumor shrinks. This technology acts like a high-definition metabolic camera that spots whether cancer cells are actually dying in real-time. It stops patients from wasting time on treatments that don't work and prevents them from suffering unnecessary side effects.

By the numbers
250M€
Expected cumulative revenues 5 years post-market
100,000€
Cost per patient for some cancer immunotherapies
15-20%
Overall success rates of some cancer immunotherapies
3-4 months
Current time to evaluate treatment response
The business problem

What needed solving

Clinicians currently rely on a trial-and-error approach to cancer treatment, waiting 3-4 months to see if a tumor shrinks. This leads to patients suffering side effects from ineffective drugs and wastes expensive medical resources.

The solution

What was built

A Hyperpolarized Magnetic Resonance (HypMR) imaging system and associated contrast agents to detect treatment response in days.

Audience

Who needs this

MRI hardware manufacturersOncology pharmaceutical companiesPrivate diagnostic imaging centersPrecision medicine clinics
Business applications

Who can put this to work

Medical Device Manufacturing
enterprise
Target: MRI Hardware Producer

If you are a hardware producer dealing with the need for higher diagnostic precision — this project developed Hyperpolarized Magnetic Resonance (HypMR) imaging that allows radiologists to see tissue metabolism in real-time. This enables the commercialization of clinical polarizers and consumables.

Pharmaceuticals
enterprise
Target: Oncology Drug Developer

If you are a drug developer dealing with low success rates in expensive immunotherapies, which can cost more than €100,000 per patient — this project developed a way to track drug effects in real-time. This allows for faster validation of treatment efficacy during clinical trials.

Healthcare Providers
mid-size
Target: Private Diagnostic Clinic

If you are a clinic dealing with the trial-and-error approach of chemotherapy where results take 3-4 months to confirm — this project developed a molecular imaging modality that detects non-responders after the first treatments. This improves patient outcomes and reduces wasted resources.

Frequently asked

Quick answers

What is the expected revenue potential of this technology?

Commercialization of the clinical polarizer and consumables, including the contrast agent, is expected to generate cumulative revenues of more than 250M€ within 5 years post-market entry.

Can this be scaled to other types of cancer or diseases?

Yes, while breast cancer is the first use case, the technology is designed to characterize prostate cancer, other cancers, cardiometabolic diseases, and neurodegenerative diseases.

Who owns the intellectual property or licensing?

Based on available project data, the project involves a consortium of 6 partners including the SME Polarize, which is positioned to use the R&D for commercialization and raising capital.

How does this impact the cost of cancer treatment?

It targets the reduction of spending on non-effective treatments, such as immunotherapies that can cost over €100,000 per patient with only 15-20% success rates.

What is the timeline for clinical implementation?

The project runs from June 2024 to September 2027, focusing on R&D towards multicenter clinical studies and market entry.

Consortium

Who built it

The consortium is heavily academic, with 5 universities and only 1 SME (Polarize), resulting in an industry ratio of 17%. This structure suggests the project is in a transition phase where high-level research from Denmark, Germany, and Israel is being funneled into a single commercial vehicle (the SME) to prepare for capital investment and clinical trials.

How to reach the team

Contact Aarhus Universitet regarding the RESPONSE project coordination.

Next steps

Talk to the team behind this work.

Contact us to connect with the SME Polarize for early licensing opportunities.

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