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RESORB · Project

Dissolvable Implantable Sensors for Real-Time Chemotherapy Monitoring and Personalized Dosing

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Imagine a tiny sensor, the size of a cent coin, that sits under your skin and tells your doctor exactly how much medicine is in your blood in real time. Instead of taking blood samples and sending them to a lab, the data goes straight to a smartphone. When the treatment is over, the sensor simply melts away safely inside your body, so you don't need a second surgery to remove it.

By the numbers
0.1–10 µg mL⁻¹
Doxorubicin detection range for d-MIPs
12 weeks
Stability under physiological conditions
2.7 ng mL⁻¹
Limit of Detection (LoD) for d-MIP/nPSiO2 sensors
125×
Fluorescence gain for HSA-based nPSiO2 sensors
The business problem

What needed solving

Current chemotherapy monitoring relies on external blood tests that provide only a snapshot of drug levels. This lacks the real-time, localized data needed to optimize dosing and avoid toxicity.

The solution

What was built

A bioresorbable sensing system including molecularly imprinted polymers (d-MIPs) for doxorubicin detection, thermoresponsive hydrogels for protection, and HSA-agarose optical fibers.

Audience

Who needs this

Oncology drug manufacturersImplantable medical device companiesPersonalized medicine clinicsBiocompatible polymer developers
Business applications

Who can put this to work

Oncology Pharmaceuticals
enterprise
Target: Drug developers specializing in chemotherapy

If you are a drug developer dealing with unpredictable patient responses to doxorubicin — this project developed bioresorbable sensors that detect drug levels from 0.1 to 10 µg mL⁻¹. This allows for fine-tuning the dose at the tumor site to increase patient survival rates.

Medical Device Manufacturing
mid-size
Target: Implantable biosensor manufacturers

If you are a device manufacturer dealing with the risks of surgical retrieval and infection — this project developed a system with on-demand degradation. The device is fully RESORBed using an external temperature-trigger, eliminating the need for retrieval surgery.

Digital Health
any
Target: Remote patient monitoring platform providers

If you are a digital health provider dealing with the gap between clinic visits and real-time data — this project developed a sensor that communicates wirelessly with a smartphone. This transforms healthcare from single-point testing to dynamic, personalized medical feedback.

Frequently asked

Quick answers

What is the cost or price of the sensor?

Based on available project data, there is no specific pricing or unit cost mentioned for the sensing system.

Can this be produced at an industrial scale?

The project focuses on demonstrating fabrication and operation in animal models; industrial scaling details are not provided in the current report.

What is the IP and licensing status?

Based on available project data, specific patent numbers or licensing terms are not listed, though the project developed specific d-MIPs and hydrogel formulations.

How long does the sensor last before dissolving?

The project demonstrated stability under physiological conditions for 12 weeks or more.

How is the sensor integrated into the patient's body?

The system is implanted beneath the skin and is designed to be the size of 1 EuroCent.

Consortium

Who built it

The consortium is heavily academic, consisting of 7 partners from 4 countries (FR, IT, PT, UK). With 6 universities and 1 research organization, there is a 0% industry ratio, indicating the project is currently in a high-research phase rather than a commercialization phase.

How to reach the team

Contact Università di Pisa

Next steps

Talk to the team behind this work.

Contact us to find industrial partners for the commercialization of bioresorbable sensors.

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