SciTransfer
PROSPLIGN · Project

Extracting High-Value Bioactive Ingredients from Industrial Lignin Waste for Pharma and Cosmetics

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Imagine lignin as a giant, locked treasure chest found in wood waste and paper mills. Most people just burn it for heat because they can't find the key to open it. This project creates a set of chemical and biological 'keys' to unlock the chest and find rare, valuable molecules inside that can be used in medicines and creams.

By the numbers
1.4 trillion
Combined market size of pharmaceuticals, cosmetics, and fragrances in Euro
9
Number of lignin species used
17
Number of different bioactivity assays for screening
1000
Maximum number of lignin-derived compound mixtures to be investigated
The business problem

What needed solving

High-value sectors like pharma and cosmetics struggle to find sustainable, natural bioactive ingredients. Meanwhile, lignin—a massive industrial by-product—is wasted because current processing methods destroy its valuable chemical structures.

The solution

What was built

A reproducible bioprospecting pipeline combining chemical and enzymatic methods to isolate and validate bioactive molecules from lignin.

Audience

Who needs this

Pharmaceutical R&D departmentsCosmetic formulation labsFragrance chemical manufacturersPulp and paper mills seeking waste valorization
Business applications

Who can put this to work

Pharmaceuticals
enterprise
Target: Drug discovery and development firms

If you are a drug developer dealing with the high cost of discovering new bioactive leads — this project developed a pipeline to isolate novel small molecules from 9 different lignin species that can be screened via 17 different bioactivity assays.

Cosmetics
SME
Target: Natural skincare and beauty brands

If you are a beauty brand dealing with the need for sustainable, plant-based active ingredients — this project developed a method to turn underutilised industrial by-products into high-value bioactive motifs for skin care.

Fragrances
mid-size
Target: Perfume and aroma chemical manufacturers

If you are a fragrance house dealing with the scarcity of natural aromatic compounds — this project developed a way to unlock a 'biomass mine' of lignin to find new scent molecules without invasive harvesting.

Frequently asked

Quick answers

What is the estimated cost of the production process?

Based on available project data, specific costs are not provided, but the project will use Techno-Economic Assessment (TEA) to confirm the economic viability of the production methods.

Can this be scaled to an industrial level?

Yes, the project aims to create a reproducible and scalable pipeline and will use Life Cycle Analysis (LCA) to ensure scalability and alignment with EU Green Deal goals.

How is the intellectual property or licensing handled?

Based on available project data, specific licensing terms are not mentioned, but the project focuses on designing sustainable production pathways for at least 2 promising compounds per sector.

What is the timeline for market entry?

The project runs from 2024-01-01 to 2027-06-30, suggesting that validated compounds and production routes will be available by mid-2027.

How does this integrate into existing paper mill operations?

The project treats lignin, a common by-product of pulp and paper industries, as a feedstock, turning a waste stream into a raw material for high-tech applications.

Consortium

Who built it

The consortium is well-balanced for a translation project, consisting of 7 partners across 6 countries. With an industry ratio of 29% (including 2 SMEs), there is a clear bridge between the 4 universities and 1 research institute and the commercial market, led by an SME coordinator (Kelada Pharmachem Limited).

How to reach the team

Contact Kelada Pharmachem Limited in Ireland for partnership opportunities regarding lignin-derived bioactives.

Next steps

Talk to the team behind this work.

Contact us to find out how to license the validated bioactive motifs from the PROSPLIGN pipeline.

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