SciTransfer
PHIRE · Project

AI-Powered Imaging and Thermal Therapy for Eliminating Microscopic Bladder Cancer

healthTestedTRL 6

Imagine trying to find and remove a tiny seed in a large field, but the seed is invisible to the naked eye. This technology uses special gold particles that stick to cancer and a high-tech camera to light them up. Once found, a laser heats those particles to burn away the cancer without harming the surrounding area.

By the numbers
600,000
patients per year
10 billion
annual cost of bladder cancer management (USD)
1 mm
minimum tumor size targeted for detection
The business problem

What needed solving

Current surgical and therapeutic methods fail to detect and treat bladder tumors smaller than 1 mm, leading to high relapse rates. This inefficiency contributes to a $10 billion annual healthcare burden.

The solution

What was built

A theranostic system comprising an add-on photoacoustic imaging module, AI-driven prediction software, and GMP-compliant targeted gold nanorods.

Audience

Who needs this

Urology clinic networksMedical imaging device manufacturersNanomedicine pharmaceutical companiesAI healthcare software providers
Business applications

Who can put this to work

Medical Device Manufacturing
enterprise
Target: Endoscopy equipment manufacturer

If you are an endoscopy equipment manufacturer dealing with the limitation of current cystoscopes that cannot see tumors < 1 mm — this project developed an add-on imaging module and AI map that enables the detection and treatment of these invisible lesions.

Nanotechnology
SME
Target: Specialized pharmaceutical producer

If you are a pharmaceutical producer dealing with the difficulty of creating stable, clinical-grade nanoparticles — this project developed a large-scale synthesis process for urine-stable gold nanorods produced under GMP standards.

Health Software
any
Target: AI diagnostic software developer

If you are a software developer dealing with the lack of precision in guided thermal therapies — this project developed an AI-assisted prediction map that guides the eradication of chemoresistant neoplastic lesions.

Frequently asked

Quick answers

How does this impact the cost of cancer management?

Based on available project data, the solution aims to reduce the social cost of bladder cancer management, which is currently estimated at $10 billion per year.

Is the production of the gold nanorods scalable for industry?

Yes, the consortium has started activities for industrial production, assessing critical steps for scale-up and identifying GMP regulatory requirements.

What is the intellectual property status?

A patent regarding the targeted gold nanorods (KER2) was filed on March 28, 2024, and business models for KER1 and KER2 have been identified.

What are the regulatory requirements for the nanoparticles?

The project is specifically identifying regulatory requirements to ensure production follows Good Manufacturing Practices (GMP).

What is the timeline for clinical readiness?

The project runs from September 2023 to August 2026, moving the technology from TRL 4 to TRL 6.

Consortium

Who built it

The consortium is highly industry-weighted with an 80% industry ratio, consisting of 4 industrial partners (including 2 SMEs) and 1 university across 4 countries (BE, IT, NL, UK). This structure suggests a strong focus on commercialization and manufacturing rather than pure academic research, led by Ospedale San Raffaele SRL.

How to reach the team

Contact Ospedale San Raffaele SRL in Italy

Next steps

Talk to the team behind this work.

Contact us to explore licensing opportunities for the KER1 and KER2 technologies.

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