If you are an immunotherapy developer dealing with the fact that 60-80% of patients fail to respond to treatment — this project developed a microfluidic device and software that identifies the most relevant neoantigens to increase the chance of success.
Rapid Microfluidic Platform for Personalized Cancer Immunotherapy Target Identification
Imagine trying to find a specific needle in a haystack, where the needle is a unique protein on a cancer cell. Current methods are like searching by hand for days using expensive tools. This technology acts like a high-powered magnet and a smart filter, quickly pulling out the exact targets needed to create a custom-made medicine for a patient.
What needed solving
Current neoantigen identification is too slow, expensive, and complex, limiting personalized immunotherapy to a few elite labs. This results in 60-80% of patients not responding to treatment.
What was built
A microfluidic immunopurification device combined with a peptide prioritization algorithm and mass spectrometry integration.
Who needs this
Who can put this to work
If you are a clinic dealing with long and resource-demanding antigen identification processes — this project developed PeptiCHIP which provides rapid, accurate results using minimal sample amounts and lower costs.
If you are a research institute dealing with the lack of standard methods to identify antigens for autoimmune or infectious diseases — this project developed a platform that identifies relevant antigens without needing prior knowledge of their sequences.
Quick answers
How does this affect the cost of neoantigen identification?
Based on available project data, PeptiCHIP is designed to be low-cost and reduces the need for expensive laboratory equipment and consumables compared to current resource-demanding methods.
Can this be scaled for industrial use?
The project is currently in the pre-clinical validation and demonstration phase to generate evidence for investors and create a transition-to-market plan.
Who owns the intellectual property and is it available for licensing?
The IP was protected following a Proof of Concept at the University of Helsinki, and Valo Therapeutics holds full rights to develop, exploit, and commercialize the technology.
What is the timeline for clinical availability?
The project period runs from 2023-04-01 to 2025-09-30, focusing on pre-clinical validation and the transition-to-market plan.
How does this integrate with existing lab workflows?
PeptiCHIP integrates a microfluidic purification device with mass spectrometry analysis and a specific prioritization software to simplify the antigen profiling process.
Who built it
The project is led by a single partner, Valo Therapeutics OY, a Finnish SME. With a 100% industry ratio, the project is streamlined for commercial exploitation, moving directly from a university-proven concept to a business-led pre-clinical validation phase.
Contact Valo Therapeutics OY in Finland
Talk to the team behind this work.
Contact us to explore licensing opportunities for PeptiCHIP technology.