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PEP4LEP 2.0 · Project

Optimizing Community-Based Screening and Preventive Treatment for Leprosy and Skin Diseases in Africa

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Imagine trying to stop a fire by finding the smallest sparks before they spread. Instead of waiting for sick people to visit a clinic, teams go directly into villages to check everyone's skin and give a single preventive dose of medicine to those at risk. This helps find cases much faster and prevents permanent disability across large populations.

By the numbers
22,563
contacts screened
20,356
contacts received SDR-PEP
282
new leprosy cases detected
10,436
individuals diagnosed with skin conditions
The business problem

What needed solving

High case detection delays in leprosy lead to permanent disability and continued transmission. Current health-centre-based screening is often inaccessible to high-risk populations in rural Africa.

The solution

What was built

A two-arm implementation trial comparing community-based skin camps (screening 100 contacts per case) versus health-centre-based screening.

Audience

Who needs this

Pharmaceutical companies specializing in NTDsmHealth software providersInternational health insurance providersGlobal health NGOsPublic health ministries in endemic regions
Business applications

Who can put this to work

Pharmaceuticals
enterprise
Target: Generic drug manufacturer

If you are a drug manufacturer dealing with unpredictable demand for rifampicin in emerging markets — this project developed a scalable delivery model that has already administered SDR-PEP to 20,356 contacts. This provides a clear roadmap for volume forecasting and distribution logistics.

Digital Health
SME
Target: mHealth app developer

If you are a software company dealing with low healthcare worker capacity in rural areas — this project utilized mHealth apps to organize skin camps and track 22,563 screened contacts. This proves the viability of digital tools for managing large-scale field screenings.

Public Health Services
any
Target: International health NGO

If you are an NGO dealing with high case detection delays in endemic regions — this project developed a community-based 'skin camp' model that screened 100 contacts per index case. This increases the efficiency of finding new leprosy cases compared to traditional clinic-based methods.

Frequently asked

Quick answers

What is the cost-effectiveness of the intervention?

Based on available project data, the project is currently collecting data on cost-effectiveness and modelling long-term economic impact to determine the most efficient screening method.

Can this be scaled to an industrial or national level?

The project is testing scalability by comparing community-based camps against health-centre-based screening across three different countries (Ethiopia, Mozambique, and Tanzania).

Are there any patents or licenses available?

Based on available project data, there is no mention of intellectual property or licensing; the focus is on implementation research and evidence-based strategies.

How does the project handle regulatory requirements for drug administration?

The intervention follows World Health Organization (WHO) guidance for administering single-dose rifampicin post-exposure prophylaxis (SDR-PEP).

What is the timeline for the results?

The project period runs from 2024-04-01 to 2026-03-31, with significant enrolment milestones already reached by March 2025.

Consortium

Who built it

The consortium consists of 6 partners across 5 countries, characterized by a total absence of industrial partners (0%). It is led by a non-governmental organization (NEDERLANDSE STICHTING VOOR LEPRABESTRIJDING) and supported by 2 universities and 2 research institutions, indicating a strong academic and field-implementation focus rather than a commercial one.

How to reach the team

Contact the Nederlandse Stichting voor Leprabestrijding for implementation data.

Next steps

Talk to the team behind this work.

Request a detailed analysis of the mHealth tools used in these skin camps.

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