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NeuroSolve · Project

Optimizing Treatment and Diagnosis Pathways for Neurocysticercosis in Sub-Saharan Africa

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Imagine a parasite from pork that travels to the brain and causes seizures. This project is testing a better combination of medicines and a blood test to find the disease faster. It's like upgrading a broken GPS system to help doctors get patients to the right treatment more efficiently.

By the numbers
2.56–8.30 millions
people affected by NCC worldwide
212
human deaths per year in Tanzania due to Taenia solium
60%
epilepsy cases in endemic areas caused by Taenia solium
11
Postgraduate students recruited (8 PhDs, 3 MScs)
The business problem

What needed solving

WHO guidelines for neurocysticercosis are ignored in national policies, leaving millions of patients without optimal treatment. This leads to high rates of preventable epilepsy and death in endemic regions.

The solution

What was built

A validated combined antiparasitic treatment regimen and a serological testing implementation strategy. It also includes training materials for healthcare workers.

Audience

Who needs this

Anti-parasitic pharmaceutical companiesDiagnostic kit manufacturersInternational health NGOsAfrican national health ministries
Business applications

Who can put this to work

Pharmaceuticals
enterprise
Target: Anti-parasitic drug manufacturer

If you are a drug manufacturer dealing with low adoption of existing treatments — this project developed a combined treatment regimen that improves quality of life. This provides a validated clinical pathway for expanding market reach in Tanzania and Zambia.

Medical Diagnostics
mid-size
Target: IVD (In Vitro Diagnostics) company

If you are a diagnostics company dealing with imprecise screening for zoonotic diseases — this project evaluated the impact of serological testing on patient outcomes. This data helps in positioning blood tests as a cost-effective alternative to expensive imaging.

Public Health Consulting
SME
Target: Health systems integrator

If you are a consultancy dealing with the gap between WHO guidelines and national policy — this project developed an implementation strategy to remove barriers to uptake. This can be used as a blueprint for deploying other health technologies in endemic regions.

Frequently asked

Quick answers

What is the cost-effectiveness of the proposed treatment?

The project specifically includes a work package to demonstrate the cost-effectiveness and cost-benefit of the proposed health technologies. Based on available project data, the exact monetary savings are not yet listed.

Can this be scaled to other regions?

The project is currently being validated in Tanzania and Zambia. It aims to provide a blueprint for implementation research that can be applied to other healthcare systems.

Are there patents or licenses available for the serological test?

Based on available project data, there is no mention of specific patents or licensing terms; the focus is on evaluating the impact of existing serological testing.

How does this affect national health regulations?

The project engages policy and decision-makers to ensure research results are integrated into national and international guidelines.

What is the timeline for the clinical results?

The project period runs from 2023-05-01 to 2027-04-30, suggesting results will be finalized by April 2027.

Consortium

Who built it

The consortium is heavily academic, consisting of 4 universities and 1 other entity across 4 countries (BE, IT, TZ, ZM). With 0% industry participation, the project is currently driven by research and clinical validation rather than commercial development, though it is coordinated by an Italian SME-type social enterprise.

How to reach the team

Contact R-EVOLUTION WORLDWIDE SRL for details on the implementation strategy.

Next steps

Talk to the team behind this work.

Contact us to identify potential diagnostic partners for the serological test validation.

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