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NanoXCAN · Project

Tabletop X-ray Microscope for High-Resolution Virus and Protein Imaging

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Imagine trying to take a photo of a tiny virus, but the only cameras capable of it are the size of a city block and located in just a few places in Europe. This project is building a compact, desk-sized version of that giant machine. It uses a powerful laser to create a tiny, intense X-ray beam that can see through biological samples without destroying them.

By the numbers
100keV
X-ray radiation limit in experimental hall
3 mJ
Pulse energy
30 fs
Pulse duration
1 MHz
Pulse repetition rate
3 kW
Average power
The business problem

What needed solving

Imaging single viruses currently requires access to a few massive, specialized synchrotron centers in Europe. This creates a bottleneck for hospitals and drug developers who need rapid, non-destructive structural analysis of viruses to create treatments.

The solution

What was built

A tabletop X-ray microscope system including a high-average-power laser, a nano-source of hard X-rays, and ML-enhanced image reconstruction software.

Audience

Who needs this

Biopharmaceutical R&D firmsViral research institutesHigh-end optical component manufacturersClinical diagnostic laboratories
Business applications

Who can put this to work

Pharmaceuticals
enterprise
Target: Antiviral drug developer

If you are a drug developer dealing with the slow process of identifying viral protein structures — this project developed a tabletop X-ray microscope that allows for in-situ, non-destructive imaging of single viruses. This enables faster design of antiviral treatments without needing access to a synchrotron.

Medical Diagnostics
mid-size
Target: Hospital research laboratory

If you are a hospital lab dealing with the inability to image viruses on-site — this project developed a compact X-ray nano-source that brings synchrotron-level power to a tabletop setup. This allows for immediate characterization of infectious diseases within the clinical environment.

Optical Components
SME
Target: Laser coating manufacturer

If you are a component manufacturer dealing with materials that degrade under high-power beams — this project developed High-Damage-Threshold Coatings via NANEO to support MHz repetition rates. This technology ensures hardware survives the 3 kW average power required for nanoscale imaging.

Frequently asked

Quick answers

What is the estimated cost of the system?

Based on available project data, the specific commercial price is not listed, though the EU research contribution for development is EUR 3,723,551.

Can this be scaled for industrial use?

The project aims to move from specialized centers to a 'tabletop' format, suggesting a significant shift toward industrial and clinical scalability.

Who owns the IP or licensing rights?

Based on available project data, the IP is managed by a consortium of 8 partners, including 4 industry players and 2 SMEs, but specific licensing terms are not provided.

How long does it take to get a result?

The system is being developed for MHz-rate data acquisition, which indicates high-speed imaging capabilities.

How does it integrate with existing lab workflows?

It is designed as a tabletop microscope, meaning it is intended to fit into standard laboratory spaces rather than requiring a dedicated radiation facility like a synchrotron.

Consortium

Who built it

The consortium is highly balanced for commercialization, featuring an industry ratio of 50% with 4 industrial partners, including 2 SMEs. With 8 partners across 6 countries, the group combines academic research (2 universities, 2 research centers) with specialized industrial capabilities in laser coatings and sensors, reducing the gap between lab discovery and market product.

How to reach the team

Contact IST-ID Associacao in Portugal

Next steps

Talk to the team behind this work.

Contact us to connect with the NanoXCAN consortium for licensing discussions.

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