If you are a drug manufacturer dealing with high batch failure rates that can cost billions—this project developed a multi-sensor-on-a-chip that provides real-time monitoring of glucose and pH. This reduces the risk of losing entire production runs and speeds up the development of new therapies.
On-chip real-time monitoring system to reduce failures in biopharmaceutical drug production
Imagine a tiny, high-tech chip that acts like a digital eye inside a drug-growing tank. Instead of taking samples out and testing them in a lab, this chip uses light to 'see' exactly how much sugar or acid is present in real-time. It's like having a continuous health monitor for medicine, ensuring the batch doesn't spoil.
What needed solving
Biopharmaceutical companies suffer massive financial losses due to high batch failure rates in cell culture. Existing sensors are often imprecise, prone to fouling, and incompatible with single-use sterilization processes.
What was built
A miniaturized fiber-attached sensor chip and a full system architecture including an optical control unit and software for real-time biochemical monitoring.
Who needs this
Who can put this to work
If you are a hardware provider dealing with sensors that break or foul during sterilization—this project developed a miniaturized fiber-attached sensor chip. This allows your single-use tanks to have high-performance, integrated sensing without compromising the disposable nature of the equipment.
If you are a biotech startup dealing with complex, highly regulated cell culture processes—this project developed a non-invasive monitoring platform. This ensures tighter process control and higher product quality for life-saving drugs.
Quick answers
How does this reduce production costs?
Based on available project data, it addresses bioprocessing failure rates that incur over $2 billion in annual losses for companies like Johnson & Johnson by providing real-time, in-situ monitoring.
Can this be used in industrial-scale production?
Yes, the project has already conducted laboratory and pilot scale tests in relevant fermentation and cell culture conditions to confirm stable signal generation.
What is the IP or licensing status?
Based on available project data, the technology is developed by InSpek, an SME, but specific licensing terms are not provided in the dataset.
Is the sensor compatible with industry sterilization standards?
The project explored packaging concepts specifically compatible with autoclaving and single-use environments to prevent polymer damage.
How is the system integrated into existing workflows?
The system consists of a sensor chip, an optical control unit, and software, designed for non-invasive integration into bioreactors.
Who built it
The project is led by a single partner, InSpek, which is a French SME. This 100% industry-led consortium indicates a strong commercial drive and a direct path to market, as the developer is an agile company focused on a specific industrial pain point rather than academic research.
Contact InSpek in France for partnership or licensing inquiries.
Talk to the team behind this work.
Contact SciTransfer to explore integration of MultiSpek sensors into your bioprocessing line.