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Microb-AI-ome · Project

AI-Driven Colorectal Cancer Screening and Personalized Therapy via Privacy-Preserving Microbiome Data

healthPrototypeTRL 4

Imagine if doctors could predict who really needs an invasive colonoscopy just by looking at the bacteria in their gut. Instead of moving sensitive patient records to one giant, risky cloud, this system lets AI 'visit' different hospital databases to learn patterns without ever taking the data away. It's like a teacher visiting different classrooms to learn from students without moving the students out of their schools.

By the numbers
20 billion EUR
Annual economic burden of colorectal cancer in the EU
20 percentage points
Target increase in specificity for predicting colonoscopy need
100,000
Expected total metagenomes covered by 2026
5,000
Initial number of individuals screened for CRC in the network
The business problem

What needed solving

Colorectal cancer causes a 20 billion EUR annual economic burden in the EU. Current screening methods lack the specificity to accurately predict who needs expensive and invasive colonoscopies.

The solution

What was built

A prototype for local database nodes (Microb-AI-Clients) and a set of harmonized data standards for federated AI training.

Audience

Who needs this

Diagnostic lab operatorsHealth data privacy software vendorsPrecision oncology pharmaceutical companiesPublic health screening agencies
Business applications

Who can put this to work

Diagnostics
mid-size
Target: Medical testing laboratory

If you are a medical testing laboratory dealing with low specificity in faecal immunological tests (FIT) — this project developed an AI stratification technology that aims to increase specificity by >20 percentage points using metagenomic microbiomes.

Health IT
SME
Target: Medical data software provider

If you are a medical data software provider dealing with strict privacy regulations that hinder data integration — this project developed a federated database network that allows AI training without sensitive patient data leaving local safe harbours.

Pharmaceuticals
enterprise
Target: Precision medicine drug developer

If you are a precision medicine drug developer dealing with the need for better patient stratification for therapy — this project developed computational microbiome profiles to allow for optimised personal therapy stratification in colorectal cancer.

Frequently asked

Quick answers

What is the cost or price of implementing this system?

Based on available project data, there is no specific pricing or cost information provided for the implementation of the technology.

Can this be scaled to a large number of patients?

Yes, the project aims to integrate metagenomes for over 5,000 individuals initially, with an expected total of 100,000 by 2026.

What are the IP and licensing terms for the AI models?

Based on available project data, specific IP and licensing details are not mentioned; however, the project involves a consortium of 8 partners including 3 SMEs.

How does the system handle GDPR and privacy regulations?

The project uses a federated database network rather than a cloud, ensuring no sensitive patient data leaves the local databases while still allowing AI classification of phenotypes.

What is the timeline for clinical adoption?

The project period runs from 2023-04-01 to 2028-03-31, with the goal of demonstrating results in clinical practice to help regulatory bodies adopt evidence-based guidelines.

Consortium

Who built it

The consortium is well-balanced for a translation project, consisting of 8 partners across 5 countries. With a 38% industry ratio (3 companies, including 3 SMEs), there is a strong focus on commercial viability and software development alongside the academic expertise of 2 universities and 2 research institutes.

How to reach the team

Contact the University of Hamburg research office regarding the Microb-AI-ome project.

Next steps

Talk to the team behind this work.

Contact us to explore licensing opportunities for federated AI in medical diagnostics.

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