SciTransfer
LIBRA · Project

Smart Light-Based Sensing System for Real-Time Bioreactor Contamination and Nutrient Monitoring

manufacturingTestedTRL 5

Imagine a high-tech 'blood test' for industrial vats that tells you instantly if your batch is healthy or contaminated. Instead of waiting days for lab results, this device uses light chips to spot bad bacteria and food levels in real-time. It's like having a smart security camera and a nutritionist for your bioreactor all in one small box.

By the numbers
6.6 B€
Predicted bioreactor market size by 2030
50%
Target reduction in energy consumption
59 million
Expected market revenues by 2032
2.3x
Achieved preconcentration factor
The business problem

What needed solving

Bioreactor production is plagued by contamination risks and inefficient nutrient monitoring, which threatens the sustainability and competitiveness of bioproducts. There is currently no universal solution for real-time, in-line screening of these processes.

The solution

What was built

A benchtop smart multi-sensing system featuring miniaturized Photonic Integrated Circuits (PICs), disposable microfluidic modules, and AI-driven data analysis for pathogen and nutrient detection.

Audience

Who needs this

Biopharmaceutical manufacturersBioreactor equipment OEMsSynthetic biology startupsBio-fuel production plants
Business applications

Who can put this to work

Biopharmaceuticals
enterprise
Target: Drug manufacturer

If you are a drug manufacturer dealing with expensive batch failures due to contamination — this project developed a benchtop multi-sensing system that provides real-time screening of pathogens. This ensures reliable production and reduces waste throughout the value chain.

Synthetic Biology
mid-size
Target: Bio-based materials producer

If you are a bio-materials producer dealing with inefficient nutrient feeding — this project developed interchangeable photonic modules that screen nutrients in-line. This can lead to a 50% reduction in energy consumption during the production process.

Bioprocess Equipment
any
Target: Bioreactor OEM

If you are a bioreactor manufacturer dealing with a lack of integrated sensing options — this project developed a system that attaches to various form factors, from stirred tanks to single-use bioreactors. This allows you to offer a smart, automatable screening upgrade to your customers.

Frequently asked

Quick answers

What is the expected market revenue for this technology?

Based on available project data, market revenues are expected to be €7.8 million one year after the project ends, growing to nearly €59 million by 2032.

How does this scale for industrial use?

The system is designed as a benchtop device that can be integrated into various bioreactor types, including stirred tank and single-use bioreactors (SUB).

What is the IP and licensing situation?

The project expects to generate a plethora of new IP and new business opportunities for the partners involved in the joint venture.

What are the cost savings associated with this system?

The project aims to achieve at least 50% reduced energy consumption throughout the whole bioreactor production process.

How is the system integrated into existing workflows?

It uses a modular design with interchangeable components and disposable microfluidic modules to enable flexible screening based on end-user needs.

Consortium

Who built it

The consortium is heavily industry-driven with a 75% industry ratio (15 industry partners out of 20), including 7 SMEs. This strong commercial presence, combined with 5 academic/research partners across 7 countries, indicates a high focus on commercial viability and market entry rather than pure theoretical research.

How to reach the team

Contact ETHNICON METSOVION POLYTECHNION in Greece

Next steps

Talk to the team behind this work.

Contact us to explore licensing opportunities for the LIBRA photonic sensing modules.

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