SciTransfer
LEOPARD · Project

AI-Driven Liver Transplant Prioritization and Risk Prediction Software

healthPrototypeTRL 3

Imagine a waiting list for a life-saving organ where the rules for who goes first are 20 years old and outdated. This project creates a smart AI system that acts like a high-precision triage tool to identify who is truly at the highest risk of dying. It ensures the right patients get transplants in time by using modern data instead of old formulas.

By the numbers
20
Age of current MELD model in years
40%
Current percentage of HCC candidates
10%
Percentage of HCC candidates in early 2000s
15-30%
Mortality rate in low/medium donation countries
The business problem

What needed solving

Current liver transplant allocation relies on a 20-year-old model that fails to accurately predict mortality for liver cancer (HCC) patients. This leads to inefficient organ use and high wait-list mortality rates.

The solution

What was built

An AI-based predictive algorithm for mortality stratification, professional decision-support calculators for DC and HCC, and a prototype 3rd-generation model integrating OMICS/radiomics.

Audience

Who needs this

Organ Sharing Organizations (OSOs)Liver Transplant CentersHealth AI Software VendorsPrecision Medicine Diagnostic Labs
Business applications

Who can put this to work

Healthcare Software
SME
Target: Medical AI developer

If you are a medical AI developer dealing with outdated clinical scoring systems — this project developed AI-based predictive algorithms and calculators that better stratify patient mortality risk. This allows for the creation of high-precision decision-support tools for surgeons.

Public Health Administration
enterprise
Target: Organ Sharing Organization (OSO)

If you are an OSO dealing with a 15 to 30% mortality rate in low/medium donation areas — this project developed a validated predictive algorithm to replace the 20-year-old MELD model. This reduces disparities in access to transplants across Europe.

Diagnostics
mid-size
Target: Precision Medicine Lab

If you are a lab dealing with complex liver cancer (HCC) prognosis — this project developed a 3rd-generation exploratory model integrating OMICS and radiomics signatures. This provides a deeper biological layer for predicting patient outcomes.

Frequently asked

Quick answers

What is the cost or pricing for the LEOPARD tools?

Based on available project data, no pricing or cost information is provided as this is a research-funded project.

Can this be scaled to an industrial level?

Yes, the project aims to provide tools for Organ Sharing Organizations (OSOs) to drive allocation across multiple European countries, indicating a design for large-scale institutional use.

What is the IP and licensing status of the AI algorithms?

Based on available project data, specific licensing terms are not mentioned, though the project involves a consortium of 18 partners including SMEs and research labs.

How does this integrate with existing hospital systems?

The project develops calculators and algorithms designed to be used by professionals for assistance in complex decision-making processes, likely integrating with OSO data systems.

What is the timeline for deployment?

The project period runs from 2023-11-01 to 2028-10-31, suggesting that full validation and deployment occur toward the end of this window.

Consortium

Who built it

The consortium is heavily weighted toward clinical and research expertise, featuring 18 partners across 9 countries. With 7 research institutes and 3 universities, the project is science-led, but the inclusion of 2 industry partners (including 1 SME) and 6 other organizations (likely OSOs) ensures that the AI tools are developed with practical implementation in mind.

How to reach the team

Contact Assistance Publique Hopitaux de Paris

Next steps

Talk to the team behind this work.

Contact us to explore licensing opportunities for AI-based organ allocation tools.

More in Health & Biomedical
See all Health & Biomedical projects