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IDEFIX · Project

Human-on-a-Chip Platform for Faster and More Accurate Drug Toxicity Testing

healthPilotedTRL 6

Imagine having a tiny, living version of human organs on a computer chip. Instead of testing new medicines on animals, which often gives wrong results for humans, this system uses real human tissue to see how a drug actually behaves. It's like a high-tech flight simulator for medicine, allowing doctors to test a treatment on a patient's own cells before giving it to them.

By the numbers
15
modular platforms for pre-commercialisation
7
days of patient biopsy cultivation
6
biological models developed
The business problem

What needed solving

Animal testing often fails to predict how drugs will affect humans, leading to expensive failures in clinical trials. There is also a lack of tools to test personalized drug efficacy on patient biopsies for extended periods.

The solution

What was built

A modular microfluidic platform (CubIX) with stackable modules for gas, flow, and temperature control, along with reusable moulds for disposable components.

Audience

Who needs this

Pharmaceutical R&D departmentsContract Research Organizations (CROs)Oncology research hospitalsToxicology laboratories
Business applications

Who can put this to work

Pharmaceuticals
enterprise
Target: Drug Discovery Firm

If you are a drug discovery firm dealing with high failure rates in clinical trials because animal tests are unreliable — this project developed a multiorgan MPS platform that mimics human physiology to predict toxicity and efficacy more accurately.

Biotechnology
SME
Target: Personalized Medicine Provider

If you are a personalized medicine provider dealing with the inability to predict how a specific patient will react to a drug — this project developed a system to cultivate patient biopsies for more than 7 days to test therapeutic strategies before administration.

Medical Research
any
Target: Cancer Research Institute

If you are a cancer research institute dealing with the complexity of simulating circulating metastasis — this project developed a modular platform capable of reconstructing complex tissues including the immune system and vascularization.

Frequently asked

Quick answers

What is the cost or pricing model for the IDEFIX platform?

Based on available project data, specific pricing is not disclosed, but the platform is designed as a modular system allowing users to customize it according to their budget.

Can this technology be scaled for industrial use?

Yes, the project has already started anticipating small scale production and developed reusable moulds for disposable injection mouldings to support scaling.

What intellectual property or licensing is involved?

The technology relies on patent-pending gas mixers (FR2109230) and proprietary microfluidic technologies in gas enrichment and liquid flow (EP3712244, FR3094012, US2020299631).

How does this integrate into existing laboratory workflows?

The solution is designed for seamless adaptability to current workflows and is compatible with all standard multiwell cell cultures and tissues.

What is the timeline for commercial availability?

The project ran from 2022-11-01 to 2024-08-31, aiming to reach TRL-6 and be investment-ready (IRL-7) for early adopters by the end of the period.

Consortium

Who built it

The project is led by a single SME, Cherry Biotech (FR), representing a 100% industry ratio. This lean structure suggests a highly focused commercial drive, utilizing direct partnerships with industry giants like Sanofi and research centers like Gustave Roussy Institut for validation rather than a large academic consortium.

How to reach the team

Contact Cherry Biotech in France regarding the CubIX Platform and IDEFIX modular MPS.

Next steps

Talk to the team behind this work.

Contact us to identify licensing opportunities for the IDEFIX microfluidic patents.

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