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HILIGHT · Project

High-Speed Laser Imaging for Instant Digital Biopsies and Cancer Research

healthTestedTRL 5

Imagine a camera that can take high-resolution photos of living cells so fast it's like a high-speed movie, but it can also see the chemical makeup of the tissue. Instead of waiting days for a lab to stain a tissue sample with dyes, this tool uses a tiny, powerful laser to get an immediate digital reading. It's like upgrading from a slow polaroid to a professional digital scanner for the inside of the body.

By the numbers
3–6 GHz
Laser repetition rate
5
Number of partner countries
The business problem

What needed solving

Two-photon microscopy is currently limited to specialist labs because the equipment is too bulky, expensive, and slow for real-time clinical use.

The solution

What was built

A miniaturized laser source capable of 3-6 GHz pulse bursts and a CMOS-based digital Silicon Photomultiplier (dSiPM) detector for high-speed biochemical imaging.

Audience

Who needs this

Intraoperative pathology labsCancer research institutesBiophotonic instrument manufacturersPharmaceutical R&D centers
Business applications

Who can put this to work

Medical Diagnostics
enterprise
Target: Surgical equipment manufacturer

If you are a surgical equipment manufacturer dealing with slow pathology turnaround times during surgery — this project developed a compact laser and detector system that enables near-instantaneous optical biopsy capabilities. This allows for rapid intraoperative diagnostics to improve patient outcomes.

Biotechnology
mid-size
Target: Drug discovery lab

If you are a drug discovery lab dealing with the difficulty of tracking single-cell changes in 3D cultures — this project developed a 2ph-FLIM platform that supports biochemical sensing at photon count rates far exceeding current technologies. This enables precise single-cell biochemical phenotyping.

Optical Instrumentation
SME
Target: Microscope manufacturer

If you are a microscope manufacturer dealing with the high cost and bulk of two-photon excitation systems — this project developed a miniaturized laser source with high repetition rates (3–6 GHz) that reduces manufacturing costs and size while maintaining state-of-the-art peak power.

Frequently asked

Quick answers

How does this reduce the cost of imaging systems?

The project focuses on a laser source designed for significant improvements in manufacturing cost and energy efficiency compared to current state-of-the-art systems.

Is this technology ready for industrial scale production?

Based on available project data, the project is currently in the development and demonstration phase, aiming to integrate components into existing platforms like Vivascope.

Who owns the intellectual property or licensing rights?

Based on available project data, the technology is developed by a consortium including III-V Lab, CSEM, and FBK, but specific licensing terms are not listed.

How does it integrate with existing medical hardware?

The laser and detection technologies are specifically designed for integration into the existing confocal microscopy system developed by Vivascope.

What is the timeline for the final results?

The project is scheduled to run from 2023-12-01 to 2027-11-30.

Consortium

Who built it

The consortium consists of 5 partners across 5 countries, showing a strong international reach. With a 20% industry ratio (1 industry partner and 1 SME), the group balances deep academic research (1 university, 2 research centers) with commercial application, specifically targeting the integration of the technology into Vivascope's existing hardware.

How to reach the team

Contact III-V LAB in France

Next steps

Talk to the team behind this work.

Contact us to explore licensing opportunities for high-speed 2ph-FLIM laser sources.

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