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GRIPonMASH · Project

AI-Driven Early Screening and Diagnostic Platform for Metabolic Liver Disease

healthPilotedTRL 6

Imagine a smart filter that catches liver disease long before it becomes dangerous, without needing a painful needle biopsy. It uses AI and blood tests to spot high-risk people and gives them a personalized plan for diet and exercise. Think of it as a high-tech early warning system for the liver.

By the numbers
10,000
patients at high risk to be screened
12
European Centers of Excellence
34
consortium partners
The business problem

What needed solving

Liver biopsies are invasive and risky, leading to underdiagnosis of MASH. There is a critical need for non-invasive, scalable screening tools to identify high-risk patients early.

The solution

What was built

An AI-based diagnostic platform and a set of validated lifestyle questionnaires for primary care use.

Audience

Who needs this

Medical device companiesAI health-tech startupsPharmaceutical companies specializing in NASH/MASHPrivate diagnostic laboratory chains
Business applications

Who can put this to work

Medical Diagnostics
enterprise
Target: Diagnostic kit manufacturer

If you are a diagnostic kit manufacturer dealing with the lack of non-invasive liver tests — this project developed a platform testing multi-OMICs biomarkers that provides an alternative to liver biopsies. This allows for safer, faster screening of 10,000 high-risk patients.

Digital Health
SME
Target: AI healthcare software provider

If you are an AI software provider dealing with low accuracy in disease stratification — this project developed AI-based decision support tools. These tools use biomarker combinations to improve the detection of MASH patients at the primary care level.

Pharmaceuticals
enterprise
Target: Drug developer for metabolic diseases

If you are a drug developer dealing with difficulty finding qualified patients for clinical trials — this project developed a screening platform across 12 European Centers of Excellence. This creates a streamlined way to identify and characterize high-risk patients with obesity or diabetes.

Frequently asked

Quick answers

What is the cost or pricing model for the platform?

Based on available project data, specific pricing or cost details are not provided, though the project investigates economic barriers to future adoption.

Can this be scaled to an industrial level?

Yes, the project aims to create a sustainable and scalable platform currently being rolled out across 12 clinical sites with a target of 10,000 screened patients.

How is the IP and licensing handled?

Based on available project data, specific licensing terms are not mentioned, but the consortium includes 12 industry partners, including 7 SMEs, suggesting a commercial focus.

What is the timeline for deployment?

The project runs from December 2023 to November 2027, with the first patient already screened and a pilot platform already tested at Amsterdam UMC.

How does it integrate with existing healthcare systems?

The platform is designed for use at the primary care level and is being tested in 12 European Centers of Excellence to ensure it fits into clinical workflows.

Consortium

Who built it

The consortium is heavily geared toward commercialization, featuring a 35% industry ratio with 12 industrial partners, including 7 SMEs. This blend of 10 universities and 7 research institutes across 14 countries ensures that the AI tools and biomarkers are validated in diverse clinical settings while remaining market-oriented.

How to reach the team

Contact Universitaire Medisch Centrum Utrecht

Next steps

Talk to the team behind this work.

Contact us to explore licensing opportunities for the AI-based MASH screening tools.

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