SciTransfer
EV FOx · Project

Automated Fiber-Optic System for Rapid Extracellular Vesicle Isolation and Quantification

healthPilotedTRL 7

Imagine trying to find a few specific needles in a giant haystack of biological fluid; usually, this takes forever and is very messy. This technology acts like a high-tech magnet and scanner combined, pulling out the exact 'needles' (vesicles) you need while counting them instantly. It replaces slow, manual spinning machines with a fast, automated light-based sensor.

By the numbers
>95%
EV purity
< 20 min
hands-on time for isolation
24
speed increase factor (time/24)
4x
scalability of automated platform
>5%
potential reduction in healthcare costs
The business problem

What needed solving

Current EV isolation and quantification methods are slow, costly, and imprecise, often introducing bias that hinders clinical diagnostics and bioprocessing. This lack of standardization prevents the use of EVs in reliable cancer and cardiovascular disease screening.

The solution

What was built

An automated fiber-optic platform with a sensor dip probe for label-free EV isolation and quantification, and a high-purity isolation kit.

Audience

Who needs this

Clinical diagnostic laboratoriesBiopharmaceutical R&D departmentsCell and Gene Therapy manufacturersVaccine production facilities
Business applications

Who can put this to work

Diagnostics
enterprise
Target: Cancer and Cardiovascular Diagnostic Labs

If you are a diagnostic lab dealing with slow and imprecise EV quantification in crude samples — this project developed a fiber-optic sensor dip probe that allows for accurate quantification and purity >95%. This can reduce healthcare costs by >5% through earlier diagnosis and better patient stratification.

Biopharmaceuticals
SME
Target: Cell and Gene Therapy Developers

If you are a biotech company dealing with labor-intensive ultracentrifugation that biases your samples — this project developed an automated platform that is 24 times faster and provides high purity (>95%). This enables a more reliable transition from R&D to clinical insights.

Vaccine Manufacturing
mid-size
Target: Bioprocessing Facilities

If you are a manufacturer dealing with the lack of standardized tools for EV isolation in bioreactors — this project developed a scalable (4x) automated platform. It allows for the release of quantified EVs for further content analysis with hands-on time < 20 min.

Frequently asked

Quick answers

How does this impact the cost of healthcare?

Based on available project data, the improvement in EV diagnostics for cancer and cardiovascular diseases has the potential to reduce associated healthcare costs by >5%.

Is the system scalable for industrial use?

Yes, the project objective specifies that the automated platform is scalable 4x.

What is the IP or licensing status?

Based on available project data, the technology is developed by FOX BIOSYSTEMS NV, but specific licensing terms are not provided in the summary.

How much time is saved during the isolation process?

The new method is 24 times faster than current solutions, with hands-on time reduced to < 20 min.

How does this integrate with existing crude samples?

The system uses a sensor dip probe that allows for the direct quantification of EVs from crude samples without the bias introduced by traditional filters.

Consortium

Who built it

The project is led by a single Belgian SME, FOX BIOSYSTEMS NV, with a 100% industry ratio. This lean structure suggests a highly focused commercial drive, as the coordinator is the sole developer and beneficiary of the EUR 2,499,999 EU contribution, minimizing coordination overhead and accelerating the path to market.

How to reach the team

Contact FOX BIOSYSTEMS NV in Belgium for commercial inquiries regarding the FOx affinity isolation platform.

Next steps

Talk to the team behind this work.

Contact us to explore licensing or partnership opportunities with FOX BIOSYSTEMS NV.

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