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CERTAINTY · Project

Digital Twin Software for Personalizing CAR T-Cell Cancer Therapies

healthPrototypeTRL 6

Imagine having a digital copy of a patient's body that doctors can use to test cancer treatments before actually giving them to the person. This tool acts like a flight simulator for 'living drugs,' predicting how a patient's immune system will react to modified cells. It helps doctors move away from guessing and toward a precise plan tailored to each individual.

By the numbers
17
consortium partners
8
countries involved
29%
industry ratio
6
target TRL level
The business problem

What needed solving

CAR T-cell therapies are effective but unpredictable, with some patients failing to respond or suffering severe toxicities. Doctors currently rely on a trial-and-error approach because they lack tools to predict individual patient reactions.

The solution

What was built

A multi-scale virtual twin prototype for multiple myeloma patients. It is a modular software system that uses molecular data to simulate how 'living drugs' interact with a specific patient.

Audience

Who needs this

CAR T-cell therapy manufacturersPrecision oncology clinicsMedical AI software developersHematology research centers
Business applications

Who can put this to work

Biotechnology
mid-size
Target: Cell Therapy Developers

If you are a biotech company dealing with unpredictable patient responses to CAR T cells — this project developed a virtual twin prototype that predicts treatment outcomes. This allows for better risk-adapted decision support during the drug development process.

Healthcare Software
SME
Target: Medical Device Software Providers

If you are a software provider dealing with the need for precision medicine tools — this project developed a modular software architecture for virtual twins. It follows software as medical device principles to ensure the prototype can be scaled for clinical use.

Clinical Research
enterprise
Target: Oncology Research Hospitals

If you are a hospital dealing with severe toxicities in multiple myeloma patients — this project developed a multi-scale model that integrates real-world molecular data. This helps health experts identify the most effective course of therapy for each patient.

Frequently asked

Quick answers

What is the cost or pricing model for this virtual twin?

Based on available project data, pricing and cost details are not provided as the project is currently in the research and prototype development phase.

Can this be scaled to an industrial level?

The project uses a modular software architecture and extensible ontologies, which the objective states makes the model easily transferable to other indications and cellular immunotherapies.

What is the IP and licensing status of the software?

Based on available project data, specific licensing terms are not listed, but the project is developing a research-use-only prototype following software as medical device principles.

How does this integrate into existing hospital workflows?

The virtual twin is designed to be integrated into the Digital Europe Programme ecosystem and supports decision-making from diagnosis through to late patient monitoring.

What is the timeline for clinical deployment?

The project period runs from 2023-12-01 to 2028-05-31, aiming to reach technology readiness level 6 by the end of the term.

Consortium

Who built it

The consortium is well-balanced for a translation project, consisting of 17 partners across 8 countries. With a 29% industry ratio (5 companies, including 4 SMEs), there is a strong link between the 6 universities and 4 research institutes and the commercial market, ensuring the software is developed with practical application in mind.

How to reach the team

Contact Fraunhofer Gesellschaft zur Förderung der Angewandten Forschung EV

Next steps

Talk to the team behind this work.

Contact us to explore licensing opportunities for the CAR T virtual twin prototype.

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