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CARE-IN-HEALTH · Project

Personalized Cardiovascular Prevention Tools Using Inflammation Resolution and Lipid Profiling

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Think of chronic inflammation like a fire that won't go out, which eventually damages the heart. Instead of just trying to put out the fire with chemicals that weaken the whole body, this work finds the body's own 'off-switch' for that inflammation. It uses a person's unique fat profiles to create a custom map for staying healthy.

By the numbers
49 million
people annually in Europe affected by CVD
200 billion
economic burden in Euro per year in Europe
1.9 million
deaths from CVD
20000
patients in retrospective analysis (GISSI Prevenzione and GISSI-HF)
The business problem

What needed solving

Current CVD prevention often fails because chronic inflammation is a residual risk that cannot be stopped without suppressing the entire immune system. There is a lack of personalized tools to trigger the body's own inflammation resolution.

The solution

What was built

A lipidomic profiling methodology, an AI-empowered CARE-IN-HEALTH ATLAS, a digital multi-criteria decision support system (MCDSS), and a point-of-care biosensor.

Audience

Who needs this

Medical diagnostic device manufacturersPersonalized nutrition and supplement companiesDigital health software developersCardiology clinics and hospitals
Business applications

Who can put this to work

Medical Devices
SME
Target: Point-of-care diagnostic manufacturer

If you are a diagnostic company dealing with the need for rapid cardiovascular risk screening — this project developed a point-of-care biosensor that monitors the resolution of inflammation. This allows for immediate, personalized health monitoring outside of a central lab.

Digital Health
mid-size
Target: Clinical Decision Support Software provider

If you are a software developer dealing with imprecise CVD prevention guidelines — this project developed a multi-criteria decision support system (MCDSS). It guides healthcare professionals to design personalized prevention strategies based on an AI-empowered atlas.

Nutraceuticals
any
Target: Personalized nutrition company

If you are a nutrition firm dealing with generic dietary advice for heart health — this project developed a way to determine the impact of dietary lipid interventions on inflammation. This enables the creation of personalized blueprints for dietary lipids to prevent CVD.

Frequently asked

Quick answers

What is the cost or price of the biosensor?

Based on available project data, no specific pricing or cost information for the biosensor is provided.

Is this technology ready for industrial scale?

The project is currently developing methodologies and conducting proof-of-concept clinical trials, meaning it is not yet at industrial scale.

How is the IP and licensing handled for the CARE-IN-HEALTH ATLAS?

The project data states that the ATLAS will be provided as openly accessible for the scientific community and health care professionals.

What is the timeline for the clinical trials?

The project period runs from 2023-01-01 to 2027-12-31, with the first 18 months focused on methodology and data collection.

How does the system integrate with existing healthcare workflows?

Integration is planned through a digital multi-criteria decision support system (MCDSS) designed to guide healthcare professionals in real-life settings.

Consortium

Who built it

The consortium is well-balanced for translation, consisting of 11 partners across 6 countries. With a 27% industry ratio (3 industrial partners, including 2 SMEs), there is a clear intent to move from the 7 academic/research entities toward commercial application. The presence of SMEs suggests a focus on agile development of the biosensor and digital tools.

How to reach the team

Contact the Institut National de la Santé et de la Recherche Médicale (INSERM) in France.

Next steps

Talk to the team behind this work.

Contact us to explore licensing opportunities for the lipidomic profiling methods.

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