SciTransfer
BIOASSEMBLER · Project

Low-Cost Mass Production of Multiplexed Biosensors Using Semiconductor Wafer Technology

manufacturingTestedTRL 4

Imagine printing a complex biological map directly onto a computer chip. Instead of painstakingly placing one molecule at a time, this method lets molecules organize themselves into thousands of precise spots automatically. It is like switching from hand-painting a single portrait to using a high-speed industrial printer for thousands of images at once.

By the numbers
2 min/base
Maximum cycle time for direct photolithographic DNA synthesis
50%
Industry ratio in consortium
The business problem

What needed solving

Integrating biological elements into miniaturized semiconductor sensors is currently too difficult and expensive for mass production. This has limited the availability of affordable, multiplexed biosensors for healthcare and environmental monitoring.

The solution

What was built

A bio-intelligent manufacturing process for silicon-based biosensors, including protocols for photolithographic DNA synthesis on wafers with cycle times ≤ 2 min/base.

Audience

Who needs this

MEMS sensor manufacturersPoint-of-care diagnostic companiesBiotech chip developersIndustrial food safety labs
Business applications

Who can put this to work

Healthcare Diagnostics
enterprise
Target: Medical device manufacturer

If you are a medical device manufacturer dealing with the high cost of producing multi-biomarker tests — this project developed a bio-inspired self-assembly process that allows the simultaneous deposition of tens of different biomolecules into thousands of positions on a silicon wafer. This enables the creation of sensors that measure multiple health markers from a single drop of blood or urine.

Agriculture & Food Safety
mid-size
Target: Food quality testing lab

If you are a food quality testing lab dealing with slow detection of mold toxins or antibiotics — this project developed a wafer-level biofunctionalization process that lowers production costs for bioMEMS sensors. This allows for rapid, repeatable, and low-cost screening of food samples at an industrial scale.

Environmental Monitoring
any
Target: Water utility company

If you are a water utility company dealing with expensive water quality monitoring equipment — this project developed a new encapsulation process for silicon-based biosensors. This makes the sensors cost-effective for mass manufacturing and deployment in the field to monitor water quality.

Frequently asked

Quick answers

How does this impact the production cost of biosensors?

The project uses wafer-level biofunctionalization and a new encapsulation process to significantly lower the production costs of bioMEMS sensors, making them suitable for mass manufacturing.

Can this technology be scaled for industrial use?

Yes, the bio-intelligent processes are designed to be industrial and repeatable, allowing for the simultaneous deposition of biomolecules across thousands of positions on a silicon wafer.

What is the intellectual property or licensing status?

Based on available project data, specific IP or licensing terms are not provided, but the project involves a consortium of 6 partners including 3 industry players.

How does this integrate with existing semiconductor facilities?

The technology integrates bio-inspired assembly directly into semiconductor manufacturing, utilizing silicon wafers and photolithographic synthesis to marry MEMS sensors with biotechnology.

What is the expected timeline for implementation?

The project period runs from 2022-09-01 to 2026-02-28, indicating the development phase is currently active.

Consortium

Who built it

The consortium is highly commercially oriented, with a 50% industry ratio consisting of 3 industrial partners (including 2 SMEs) and 3 research/university entities across 4 countries (AT, DE, FI, PT). This balance suggests a strong focus on translating lab-scale bio-assembly into a viable industrial manufacturing process.

How to reach the team

Contact TEKNOLOGIAN TUTKIMUSKESKUS VTT OY in Finland

Next steps

Talk to the team behind this work.

Contact us to connect with the BIOASSEMBLER consortium for licensing and integration opportunities.

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